Pluripotency without Proliferation
نویسندگان
چکیده
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.
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ورودعنوان ژورنال:
- Cell
دوره 164 شماره
صفحات -
تاریخ انتشار 2016